Molecular Internal Medicine

Endocrinology

GPER blockers as Nox downregulators: a new drug class to target chronic non-communicable diseases
M.R. Meyer, M. Barton

J Steroid Biochem Mol Biol 176, 82-87, 2018


Twenty years of G protein-coupled estrogen receptor GPER: historical and personal perspectives
M. Barton, E. J. Filardo, S.J. Lolait, P. Thomas, M. Maggiolini, E.R. Prossnitz
J Steroid Biochem Mol Biol 176, 4-15, 2018


Rapid vasodilation to raloxifene: role of estrogen receptors and off-target effects
M. Barton, E.R. Prossnitz.
Br J Pharmacol 174, 4201-4202, 2017



Obesity causes lymphatic vascular injury: time for clinical translation
M. Barton, M. Husmann
J Physiol (Lond) 594, 6807-6808, 2016


Obligatory role for GPER in cardiovascular aging and disease
M.R. Meyer, N.C. Fredette, C. Daniel, G. Sharma, K. Amann, J.B. Arterburn, M. Barton, E.R. Prossnitz.
Science Signaling 9, ra105, 2016


Estrogen signaling in the adrenal cortex: implications for blood pressure sex differences
B. Carrocia, T.M. Seccia, M. Barton, G.P. Rossi
Hypertension 68, 840-848, 2016


Estrogens and coronary artery disease: new clinical perspectives
M.R. Meyer, M. Barton
Adv Pharmacol 77, 307-360, 2016


Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER
M. Barton
Steroids 111, 37-45, 2016


G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
J Endocrinol 227, 61-69, 2015


Erratum: G Protein-coupled estrogen receptor protects from atherosclerosis
M.R. Meyer, N.C. Fredette, T.A. Howard, C. Hu, C. Ramesh, C. Daniel, K. Ammann, J.B. Arterburn, M. Barton, E.R. Prossnitz
Sci Rep 5, 13510, 2015


Nicolaus Copernicus and the rapid vascular responses to aldosterone
M. Barton, M.R. Meyer
Trends Endocrinol Metab 26, 396-398, 2015


Emerging roles of GPER in diabetes and atherosclerosis
M. Barton, E.R. Prossnitz
Trends Endocrinol Metab 26, 185-192, 2015


Estrogen biology: New insights on GPER function and clinical opportunities
E.R. Prossnitz, M. Barton
Mol Cell Endocrinol 389, 71-83, 2014


Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate
responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents

O. Baretalla, S.K. Chung, M. Barton, A. Xu, P.M. Vanhoutte
Life Sci
118, 206-212, 2014


Regulation of vascular smooth muscle tone by Adipose-Derived Contracting Factor
M.R. Meyer, N.C. Fredette, M. Barton, E.R. Prossnitz
PLoS ONE 8, e79245, 2013


Prevention and endothelial therapy of coronary artery disease
M. Barton
Curr Opin Pharmacol 13, 225-241, 2013


Mechanisms and therapy of atherosclerosis and its clinical complications
M. Barton

Curr Opin Pharmacol 13, 149-153, 2013


Cholesterol and atherosclerosis: Modulation by estrogen
M. Barton

Curr Opin Lipidol 24, 214-220, 2013


Childhood obesity: Preventing today's children from becoming tomorrow's patients
M. Barton

IFAVA Scientific Newsletter 75, 1, 2013


Childhood obesity: a life-long health risk
M. Barton

Acta Pharmacol Sin 33, 189-193, 2012


Obesity and risk of vascular disease: Importance of endothelium-dependent vasoconstriction
M. Barton, O. Baretella, M.R. Meyer
Br J Pharmacol 165, 591-602, 2012


Testosterone and secondary hypertension: New pieces to the puzzle
M. Barton, E.R. Prossnitz, M.R. Meyer

Hypertension 59, 1011-1103, 2012


The G protein-coupled estrogen receptor GPER in physiology and disease
E.R. Prossnitz, M. Barton

Nature Rev Endocrinol 7, 715-726, 2011


Obesity, insulin resistance and diabetes: sex differences and role of estrogens receptors
M.R. Meyer, D.J. Clegg, E.R. Prossnitz, M. Barton
Acta Physiol (Oxf) 203, 259-269, 2011


Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis
M. Barton
Pflügers Arch 460, 825-837, 2010


Lung cancer and hormone replacement therapy
M. Barton, M.R. Meyer, J.L. Bolton, E.R. Prossnitz
Lancet 375, 117-118, 2010


Übergewicht und kardiovaskuläres Risiko: Neues zu Pathogenese und Therapie
M.R. Meyer, C.A. Meier
Swiss Medical Forum 10, 358-362, 2010


Estrogen-independent activation of estrogen receptors
M. Barton, M.R. Meyer, E.R. Prossnitz
Hypertension 57, 1056-1057, 2011


Getting radical about obesity: new links between fat and heart disease
M. Barton, E. Haas, I. Bhattacharya
Arterioscler Thromb Vasc Biol 29, 447-448, 2009


Postmenopausal hypertension: Mechanisms and therapy
M. Barton, M.R. Meyer
Hypertension 54, 11-18, 2009


Regulatory role of G protein coupled estrogen receptor for vascular function and obesity
E. Haas, I. Bhattacharya, E. Brailoiu, M. Damjanovic, G.C. Brailoiu, X. Gao, L. Mueller-Guerre, A. Gut, R. Minotti, M.R. Meyer,
K. Amann, E. Ammann, A. Perez-Dominguez, M. Genoni, D.J. Clegg, N.J. Dun, T.C. Resta, E.R. Prossnitz, M. Barton
Circ Res 104, 288-291, 2009


Regional heterogeneity of functional changes in conduit arteries after high-fat diet
I. Bhattacharya, A.L. Mundy, C.C. Widmer, M. Kretz, M. Barton
Obesity (Silver Spring) 16, 743-748, 2008


Fat intake and cardiovascular response
M. Damjanovic, M. Barton
Curr Hypertens Rep 10, 25-31 2008


Effects of obesity on mortality in patients with unstable angina or non ST-elevation myocardial infarction
M. Barton, M. Husmann
Eur Heart J 28, 2950, 2007


Curriculum: Atherosklerotische Gefässerkrankungen und Stickstoffmonoxid (NO): Die wachsende Bedeutung von hoher Lebenserwartung und Übergewicht für die Klinik
M. Husmann, M. Keller, M. Barton
Swiss Medical Forum 50, 1008-1011, 2007


Impaired vascular function in normoglycemic mice prone to autoimmune diabetes: Role of nitric oxide
T. Traupe, P.C. Nett, B. Frank, L. Tornillo, R. Hofmann-Lehmann, L.M. Terracciano, M. Barton
Eur J Pharmacol 557,161-167, 2007


Atherosklerotische Gefässerkrankungen und Stickstoffmonoxid (NO): Die wachsende Bedeutung
von hoher Lebenserwartung und Übergewicht für die Klinik

M. Husmann, M. Keller, M. Barton
Swiss Medical Forum 50, 1008-1011, 2007


Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: Implications for diet-induced obesity
A.L. Mundy, E. Haas, I. Bhattacharya, C.C. Widmer, M. Kretz, R. Hofmann-Lehmann, R. Minotti, M. Barton
Cardiovasc Res 73, 368-375, 2007


Curriculum: Artériopathies athérosclérotique et monoxyde d’azote (NO) : l’importance clinique d’une espérance de vie plus longue et l’obésité
M. Husmann, M. Keller, M. Barton
Forum Médical Suisse 50, 1008-1011, 2007


Vaskuläre Interaktion zwischen Insulin und LDL Cholesterin
E. Haas, R. Minotti, C. Raselli, A. Hoehn, M. Barton
Dtsch Med Wochensch 132, 20, 2007


Endothelin stimulates vascular hydroxyl radical formation: effect of obesity
A.L. Mundy, E. Haas, I. Bhattacharya, C.C. Widmer, M. Kretz, K. Baumann, M. Barton
Am J Physiol Regul Integr Comp Physiol  293, R2218-R2224, 2007


Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitus
P.C. Nett, J. Ortmann, J. Celeiro, E. Haas, R. Hofmann-Lehmann, L. Tornillo, L.M. Terraciano, M. Barton
Life Sci 78, 2213-2218, 2006


Downregulation of renal endothelin-converting enzyme 2 expression in early autoimmune diabetes
J. Ortmann, P.C. Nett, J. Celeiro, R. Hofmann-Lehmann, L. Tornillo, L.M. Terraciano, M. Barton
Exp Biol Med 231, 1030-1033, 2006


Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: evidence
for endothelin release by pancreatic islet β-cells.

J. Ortmann, P.C. Nett, J. Celeiro, T. Traupe, L. Tornillo, R. Hofmann-Lehmann, E. Haas, B. Frank, L.M. Terraciano, M. Barton
Biochem Biophys Res Commun 334, 689-695, 2005


Upregulation of vascular ETB receptor gene expression after chronic ETA receptor blockade in prediabetic NOD mice
J. Ortmann, T. Traupe, P. Nett, J. Celeiro, R. Hofmann-Lehmann, M. Lange, W. Vetter, M. Barton
J Cardiovasc Pharmacol 44, S105-S108, 2004


Obesity-associated activation of angiotensin and endothelin in the cardiovascular system
M. Barton, R. Carmona, J. Ortmann, J.E. Krieger, T. Traupe
Int J Biochem Cell Biol 35, 826-837, 2003


Cardiovascular consequences of the obesity pandemic: need for action
M. Barton, J. Furrer
Exp Opin Invest Drugs 12, 1757-1759, 2003


Effects of obesity on endothelium-dependent reactivity during acute nitric oxide inhibition: modulatory role of endothelin
T. Traupe, L.V. d'Uscio, K. Muenter, H. Morawietz, W. Vetter, M. Barton
Clin Sci (Lond) 103 (Suppl. 48), 13S-15S, 2002


Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression
T. Traupe, M. Lang, W. Goettsch, K. Münter, H. Morawietz, W. Vetter, M. Barton
J Hypertens 20, 2239-2245, 2002


Hypertension, diabetes mellitus, hypercholesterolemia and endothelin B receptor-mediated renal nitric oxide release
M. Barton, L.V. d'Uscio
Circulation 101; e228-e229, 2000


Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo.
Evidence for a regulatory role of endothelin

M. Barton, R. Carmona, H. Morawietz, L.V. d'Uscio, W. Goettsch, H. Hillen, C.C. Haudenschild,
J.E. Krieger, K. Münter, T. Lattmann, T.F. Luscher, S. Shaw
Hypertension 35, 329-336, 2000